Salivary biomarkers in oral squamous cell carcinoma
Nguyen Truc Thi Hoang, Sodnom-Ish Buyanbileg, 최성원, 정효일, 조재욱, 황인성, 김성민,
소속 상세정보
( Nguyen Truc Thi Hoang ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
( Sodnom-Ish Buyanbileg ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
최성원 ( Choi Sung-Weon ) - National Cancer Center Research Institute and Hospital Oral Oncology Clinic
정효일 ( Jung Hyo-Il ) - Yonsei University School of Mechanical Engineering
조재욱 ( Cho Jae-Wook ) - InSol Co. R&D Center
황인성 ( Hwang In-Seong ) - InSol Co. R&D Center
김성민 ( Kim Soung-Min ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
Abstract
In disease diagnostics and health surveillance, the use of saliva has potential because its collection is convenient and noninvasive. Over the past two decades, the development of salivary utilization for the early detection of cancer, especially oral cavity and oropharynx cancer has gained the interest of the researcher and clinician. Until recently, the oral cavity and oropharynx cancers are still having a five-year survival rate of 62%, one of the lowest in all major human cancers. More than 90% of oral cancers are oral squamous cell carcinoma (OSCC). Despite the ease of accessing the oral cavity in clinical examination, most OSCC lesions are not diagnosed in the early stage, which is suggested to be the main cause of the low survival rate. Many studies have been performed and reported more than 100 potential saliva biomarkers for OSCC. However, there are still obstacles in figuring out the reliable OSCC salivary biomarkers and the clinical application of the early diagnosis protocol. The current review article discusses the emerging issues and is hoped to raise awareness of this topic in both researchers and clinicians. We also suggested the potential salivary biomarkers that are reliable, specific, and sensitive for the early detection of OSCC.
키워드
Squamous cell carcinoma of head and neck; Mouth neoplasm; Saliva; Biomarkers
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